Bluebrain Theory: Unterschied zwischen den Versionen – Cluster-Kopfschmerz

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If we ask any Cluster headache (CH) patient to characterize it, his first words will be EXTREME PAIN (kip scale 8-10), around the eye and surrounding area (forehead for the most) of the affected side of the head. My theory is based on an old theory (from the sixties) and on a different version but very much like the theory you can read in clusterbusters called Neurovascular headache and its treatment Hallucinogenic treatment of the ...(I prefer to call it subhallucinogenic). There are two structures involved in this type of headache, the ophthalmic artery branches and the trigeminal nerve specially those branches that run along with the branches of the opht. artery, intracraneal as well as extracraneal. No matter if it is chronic or episodic every CH has two distinctive phases.

1) NEUROLOGICAL, this phase has to do with the abnormal or absence of serotonin release at the presynaptic button, this reaction should happen as an answer to a vasodilatation stimuli (e.g. red wine). Serotonin has a vasoconstriction effect on the extracerebral intracraneal vessels through the 5HT 1B receptors. It seems that this abnormality is local, as if there is a local regulatory system that controls the tone of the artery (based on serotonin), this could explain why this headache is hemi lateral. I know that it has been mentioned that there is a sudden increase of serotonin metabolites in the urine during a CH seizure contrary to my postulate, I could agree that this happens at the very beginning of a CH seizure, all serotonin is released at one time, but there is no refill of the presynaptic vesicles resulting in less or none presence of serotonin and no vasoconstriction. Already there is a question that arises from this statement, why not give an extra dose of serotonin? Sorry but serotonin doesn't cross the brain blood barrier, then what about an extra dose of tryptophan, unfortunately this could end in a serotonin shock. That's why we need a local serotonin substitute that should activate the local 5HT 1B receptors producing a vasoconstriction of the mentioned artery. This phase is painless.

1) NEUROLOGICAL, this phase has to do with the abnormal or absence of serotonin release at the presynaptic button, this reaction should happen as an answer to a vasodilatation stimuli (e.g. red wine). Serotonin has a vasoconstriction effect on the extracerebral intracraneal vessels through the 5HT 1B receptors. It seems that this abnormality is local, as if there is a local regulatory system that controls the tone of the artery (based on serotonin), this could explain why this headache is hemi lateral.

I know that it has been mentioned that there is a sudden increase of serotonin metabolites in the urine during a CH seizure contrary to my postulate, I could agree that this happens at the very beginning of a CH seizure, all serotonin is released at one time, but there is no refill of the presynaptic vesicles resulting in less or none presence of serotonin and no vasoconstriction.

Already there is a question that arises from this statement, why not give an extra dose of serotonin? Sorry but serotonin doesn't cross the brain blood barrier, then what about an extra dose of tryptophan, unfortunately this could end in a serotonin shock. That's why we need a local serotonin substitute that should activate the local 5HT 1B receptors producing a vasoconstriction of the mentioned artery. This phase is painless.

2) VASCULAR, is as mentioned serotonin dependent. This phase depending on how fast it evolves can be divided in two subtypes;

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12.- Cluster headache: pathogenesis, diagnosis, and management. The Lancet, Arne May, volume 366, 2005

* [https://~~www~~.~~ck-wissen~~.de/~~forum/useraction.php?action=get_upload&id=10~~ A. May, Cluster headache: pathogenesis, diagnosis, and management, The Lancet 2005 (~~PDF~~)] ~~(Save local before reading)~~

* [https://doi.org/10.1016/S0140-6736(05)67217-0 A. May, Cluster headache: pathogenesis, diagnosis, and management, The Lancet 2005 (DOI)]

13.- Occipital nerve stimulation for intractable cluster headache. The Lancet, Ambrosini A. volume 369, 2007

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 If we ask any Cluster headache (CH) patient to characterize it, his first words will be EXTREME PAIN (kip scale 8-10), around the eye and surrounding area (forehead for the most) of the affected side of the head. My theory is based on an old theory (from the sixties) and on a different version but very much like the theory you can read in clusterbusters called Neurovascular headache and its treatment Hallucinogenic treatment of the ...(I prefer to call it subhallucinogenic). There are two structures involved in this type of headache, the ophthalmic artery branches and the trigeminal nerve specially those branches that run along with the branches of the opht. artery, intracraneal as well as extracraneal. No matter if it is chronic or episodic every CH has two distinctive phases.
-) NEUROLOGICAL, this phase has to do with the abnormal or absence of serotonin release at the presynaptic button, this reaction should happen as an answer to a vasodilatation stimuli (e.g. red wine). Serotonin has a vasoconstriction effect on the extracerebral intracraneal vessels through the 5HT 1B receptors. It seems that this abnormality is local, as if there is a local regulatory system that controls the tone of the artery (based on serotonin), this could explain why this headache is hemi lateral. I know that it has been mentioned that there is a sudden increase of serotonin metabolites in the urine during a CH seizure contrary to my postulate, I could agree that this happens at the very beginning of a CH seizure, all serotonin is released at one time, but there is no refill of the presynaptic vesicles resulting in less or none presence of serotonin and no vasoconstriction. Already there is a question that arises from this statement, why not give an extra dose of serotonin? Sorry but serotonin doesn't cross the brain blood barrier, then what about an extra dose of tryptophan, unfortunately this could end in a serotonin shock. That's why we need a local serotonin substitute that should activate the local 5HT 1B receptors producing a vasoconstriction of the mentioned artery. This phase is painless.
+) NEUROLOGICAL, this phase has to do with the abnormal or absence of serotonin release at the presynaptic button, this reaction should happen as an answer to a vasodilatation stimuli (e.g. red wine). Serotonin has a vasoconstriction effect on the extracerebral intracraneal vessels through the 5HT 1B receptors. It seems that this abnormality is local, as if there is a local regulatory system that controls the tone of the artery (based on serotonin), this could explain why this headache is hemi lateral.
+I know that it has been mentioned that there is a sudden increase of serotonin metabolites in the urine during a CH seizure contrary to my postulate, I could agree that this happens at the very beginning of a CH seizure, all serotonin is released at one time, but there is no refill of the presynaptic vesicles resulting in less or none presence of serotonin and no vasoconstriction.
+Already there is a question that arises from this statement, why not give an extra dose of serotonin? Sorry but serotonin doesn't cross the brain blood barrier, then what about an extra dose of tryptophan, unfortunately this could end in a serotonin shock. That's why we need a local serotonin substitute that should activate the local 5HT 1B receptors producing a vasoconstriction of the mentioned artery. This phase is painless.
 ) VASCULAR, is as mentioned serotonin dependent. This phase depending on how fast it evolves can be divided in two subtypes;
@@ Zeile 48: / Zeile 52: @@
 .- Cluster headache: pathogenesis, diagnosis, and management. The Lancet, Arne May, volume 366, 2005
-* [https://www.ck-wissen.de/forum/useraction.php?action=get_upload&id=10 A. May, Cluster headache: pathogenesis, diagnosis, and management, The Lancet 2005 (PDF)] (Save local before reading)
+* [https://doi.org/10.1016/S0140-6736(05)67217-0 A. May, Cluster headache: pathogenesis, diagnosis, and management, The Lancet 2005 (DOI)]
 .- Occipital nerve stimulation for intractable cluster headache. The Lancet, Ambrosini A. volume 369, 2007